Lindsay Sailer

Postdoc, Cornell University

NIH National Research Service Award (NRSA) Fellow

PhD (2018), Florida State University

BA (2010) University of North Florida

Email: lls222@cornell.edu

Personal webpage

 

Research Interests: social bonding, partner preference, early-life experiences, social aggression, vasopressin, oxytocin, chemogenetics, epigenetics, individual differences

Specific Interests:

I am interested in investigating how early-life adversity can alter the neurochemical integrity of brain regions and pathways important for social interactions and pair bonding. Specifically, I want to understand how the quality and quantity of parental care can shape the development of social behaviors and how exposure to stressful environments can alter social affilation and pair bonding. I plan to approach these topics by integrating genetic, epigenetic, and chemogenetic techniques to probe the function of the vasopressin and oxytocin systems.

 

Papers (from the lab):

Sailer LL , Haghani A, Zoller JA, Li CZ, Ophir AG, Horvath S (2024) Epigenetic aging studies of pair bonding in prairie voles. Scientific Reports. 14, 17439

Sailer LL, Finton CJ, Patel PP, Bogdanowicz SM, Ophir AG (2024) Dorsal CA1 lesions of the hippocampus impact mating tactics in prairie voles by shifting non-monogamous males’ use of space to resemble monogamous males. Frontiers in Behavioral Neuroscience. 18, 1355807 [PMID: 38468707] 

Haghani A, Li, CZ, Robeck, TR, Zhang J, Lu AT, et al. … Ophir AG … Sailer LL … Horvath S (2023) DNA methylation networks underlying mammalian traits. Science. 381, eabq5693.

Lu AT, Fei Z, Haghani A, Robeck TR, Zoller JA, et al. … Ophir AG … Sailer LL … Horvath S (2023) Universal DNA methylation age across mammalian tissues. Nature Aging. 3, 1144-1166.

Sailer LL, Park AH, Galvez A, Ophir AG (2022) DREADD activation of the lateral septum alters prosocial and antisocial behaviors, but not partner preferences in male prairie voles. Communications Biology. 5, 1299.

Sailer LL, Patel PP, Park AH, Moon J, Hanadari-Levy A, Ophir AG (2022) Synergistic consequences of early-life social isolation and chronic stress impact coping and neural mechanisms underlying male prairie vole susceptibility and resilience. Front Behav Neurosci. 16:931549.

Sailer LL, Haghani A, Zoller JA, Li CZ, Ophir AG, Horvath S (2020) Pair bonding slows epigenetic aging and alters methylation in brains of prairie voles. bioRxiv. doi.org/10.1101/2020.09.25.313775.